Version 5.4
Homo sapiens Gene: TACSTD2
Summary
InnateDB Gene IDBG-99210.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TACSTD2
Gene Name tumor-associated calcium signal transducer 2
Synonyms EGP-1; EGP1; GA733-1; GA7331; GP50; M1S1; TROP2
Species Homo sapiens
Ensembl Gene ENSG00000184292
Encoded Proteins
IDBP-99212
tumor-associated calcium signal transducer 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:58575423-58577773
Strand Reverse strand
Band p32.1
Transcripts
ENST00000371225 ENSP00000360269
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007601 visual perception
GO:0008283 cell proliferation
GO:0010633 negative regulation of epithelial cell migration
GO:0050678 regulation of epithelial cell proliferation
GO:0051497 negative regulation of stress fiber assembly
GO:0060675 ureteric bud morphogenesis
GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
GO:1900028 negative regulation of ruffle assembly
GO:2000146 negative regulation of cell motility
GO:2000738 positive regulation of stem cell differentiation
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016328 lateral plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051397
View Gene Order
ENSBTAG00000004381
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.23582
RefSeq NM_002353
HUGO
OMIM
CCDS CCDS609
HPRD 00672
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca