InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DOCK7

Summary

InnateDB Protein

IDBP-99362.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOCK7

Protein Name

dedicator of cytokinesis 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000340742

InnateDB Gene

IDBG-99358 (DOCK7)

Protein Structure

UniProt Annotation

Function

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. {ECO:0000269PubMed:16982419}.

Subcellular Localization

Cell projection, axon {ECO:0000269PubMed:16982419}. Note=Enriched in the developing axons of hippocampal neurons.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:11214970}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	69 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0007264	small GTPase mediated signal transduction
GO:0007409	axonogenesis
GO:0031175	neuron projection development
GO:0032863	activation of Rac GTPase activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0045200	establishment of neuroblast polarity