Version 5.4
Homo sapiens Gene: DOCK7
Summary
InnateDB Gene IDBG-99358.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOCK7
Gene Name dedicator of cytokinesis 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116641
Encoded Proteins
IDBP-99362
dedicator of cytokinesis 7
IDBP-99364
dedicator of cytokinesis 7
IDBP-295279
dedicator of cytokinesis 7
IDBP-385237
dedicator of cytokinesis 7
IDBP-813466
dedicator of cytokinesis 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:62454728-62688368
Strand Reverse strand
Band p31.3
Transcripts
ENST00000340370 ENSP00000340742
ENST00000251157 ENSP00000251157
ENST00000404627 ENSP00000384446
ENST00000454575 ENSP00000413583
ENST00000489185
ENST00000467758
ENST00000479983
ENST00000464312
ENST00000614472 ENSP00000483062
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 69 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0002244 hematopoietic progenitor cell differentiation
GO:0007264 small GTPase mediated signal transduction
GO:0007409 axonogenesis
GO:0031175 neuron projection development
GO:0032863 activation of Rac GTPase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0043473 pigmentation
GO:0045200 establishment of neuroblast polarity
Cellular Component
GO:0008180 COP9 signalosome
GO:0030424 axon
GO:0030426 growth cone
GO:0043005 neuron projection
GO:0045178 basal part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028556
View Gene Order
ENSBTAG00000019877
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.406156 Hs.731729
RefSeq NM_001271999 NM_001272000 NM_001272001 NM_001272002 NM_033407 XM_005271292 XM_005271293 XM_006710996
HUGO
OMIM
CCDS CCDS30734 CCDS60156 CCDS60157
HPRD 16833
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca