InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGB3BP

Summary

InnateDB Protein

IDBP-99393.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB3BP

Protein Name

integrin beta 3 binding protein (beta3-endonexin)

Synonyms

CENP-R; CENPR; HSU37139; NRIF3; TAP20;

Species

Homo sapiens

Ensembl Protein

ENSP00000271002

InnateDB Gene

IDBG-99389 (ITGB3BP)

Protein Structure

UniProt Annotation

Function

Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269PubMed:11713274, ECO:0000269PubMed:12244126, ECO:0000269PubMed:15082778, ECO:0000269PubMed:15254226, ECO:0000269PubMed:16622420}.

Subcellular Localization

Isoform 1: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.Isoform 2: Nucleus.Isoform 3: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic.Isoform 4: Cytoplasm.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. {ECO:0000269PubMed:11864709, ECO:0000269PubMed:7593198}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.

Experimentally validated
Total	35 [view]
Protein-Protein	28 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0008022	protein C-terminus binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006334	nucleosome assembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007067	mitotic nuclear division
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0034080	centromere-specific nucleosome assembly
GO:0043065	positive regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0097190	apoptotic signaling pathway