Version 5.4
Homo sapiens Gene: ITGB3BP
Summary
InnateDB Gene IDBG-99389.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGB3BP
Gene Name integrin beta 3 binding protein (beta3-endonexin)
Synonyms CENP-R; CENPR; HSU37139; NRIF3; TAP20
Species Homo sapiens
Ensembl Gene ENSG00000142856
Encoded Proteins
IDBP-99393
integrin beta 3 binding protein (beta3-endonexin)
IDBP-99395
integrin beta 3 binding protein (beta3-endonexin)
IDBP-593305
integrin beta 3 binding protein (beta3-endonexin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:63440770-63593721
Strand Reverse strand
Band p31.3
Transcripts
ENST00000271002 ENSP00000271002
ENST00000371092 ENSP00000360133
ENST00000492655
ENST00000489099 ENSP00000432904
ENST00000461681
ENST00000463803
ENST00000478538
ENST00000476508
ENST00000460394
ENST00000462285
ENST00000489863
ENST00000465781
ENST00000460251
ENST00000478138
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 28 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0008022 protein C-terminus binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006334 nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007067 mitotic nuclear division
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0034080 centromere-specific nucleosome assembly
GO:0043065 positive regulation of apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028549
View Gene Order
ENSBTAG00000030710
Not yet available
Pathways
NETPATH
REACTOME
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_13643
NRIF signals cell death from the nucleus pathway
REACT_11061
Signalling by NGF pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q13352
TrEMBL D3DQ59
UniProt Splice Variant
Entrez Gene 23421
UniGene
RefSeq NM_014288 NM_001206739
HUGO HGNC:6157
OMIM 605494
CCDS CCDS30736 CCDS55603
HPRD 09267
IMGT
EMBL AF175306 AK312944 AL592218 BC009929 BC014385 BX004807 CH471059 U37139
GenPept AAC50294 AAC50295 AAF00239 AAH09929 AAH14385 BAG35785 CAI15771 CAI15772 CAI18958 CAI18959 EAX06561 EAX06562 EAX06563 EAX06564
RNA Seq Atlas 23421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca