InnateDB Protein
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IDBP-99395.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ITGB3BP
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Protein Name
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integrin beta 3 binding protein (beta3-endonexin)
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Synonyms
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CENP-R; CENPR; HSU37139; NRIF3; TAP20;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000360133
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InnateDB Gene
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IDBG-99389 (ITGB3BP)
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Protein Structure
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Function |
Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. {ECO:0000269PubMed:11713274, ECO:0000269PubMed:12244126, ECO:0000269PubMed:15082778, ECO:0000269PubMed:15254226, ECO:0000269PubMed:16622420}.
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Subcellular Localization |
Isoform 1: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.Isoform 2: Nucleus.Isoform 3: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic.Isoform 4: Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. {ECO:0000269PubMed:11864709, ECO:0000269PubMed:7593198}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
35
[view]
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Protein-Protein |
28
[view]
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Protein-DNA |
6
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009601
Centromere protein R
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PFAM |
PF06729
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PRINTS |
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PIRSF |
PIRSF011860
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q13352
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PhosphoSite |
PhosphoSite-Q13352
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TrEMBL |
D3DQ59
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UniProt Splice Variant |
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Entrez Gene |
23421
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UniGene |
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RefSeq |
NP_001193668
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HUGO |
HGNC:6157
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OMIM |
605494
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CCDS |
CCDS55603
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HPRD |
09267
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IMGT |
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EMBL |
AF175306
AK312944
AL592218
BC009929
BC014385
BX004807
CH471059
U37139
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GenPept |
AAC50294
AAC50295
AAF00239
AAH09929
AAH14385
BAG35785
CAI15771
CAI15772
CAI18958
CAI18959
EAX06561
EAX06562
EAX06563
EAX06564
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