Version 5.4
Homo sapiens Protein: LEPROT
Summary
InnateDB Protein IDBP-99471.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEPROT
Protein Name leptin receptor overlapping transcript
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360104
InnateDB Gene IDBG-239811 (LEPROT)
Protein Structure
UniProt Annotation
Function Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269PubMed:18042720, ECO:0000269PubMed:19907080}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
Biological Process
GO:0046426 negative regulation of JAK-STAT cascade
GO:0060400 negative regulation of growth hormone receptor signaling pathway
GO:2000009 negative regulation of protein localization to cell surface
Cellular Component
GO:0000139 Golgi membrane
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007262 Vacuolar protein sorting 55
PFAM PF04133
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15243
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 54741
UniGene Hs.597113
RefSeq NP_059996
HUGO HGNC:29477
OMIM 613461
CCDS CCDS630
HPRD 13987
IMGT
EMBL AC119800 AK074841 BC011027 BC056250 CH471059 CR541647 CR541737 Y12670
GenPept AAH11027 AAH56250 BAG52014 CAA73211 CAG46448 CAG46537 EAX06527 EAX06531

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca