Version 5.4
Homo sapiens Gene: LEPROT
Summary
InnateDB Gene IDBG-239811.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEPROT
Gene Name leptin receptor overlapping transcript
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000213625
Encoded Proteins
IDBP-99471
leptin receptor overlapping transcript
IDBP-811602
leptin receptor overlapping transcript
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:65420587-65436007
Strand Forward strand
Band p31.3
Transcripts
ENST00000371065 ENSP00000360104
ENST00000475108
ENST00000497874
ENST00000488747
ENST00000484243
ENST00000613538 ENSP00000483521
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0046426 negative regulation of JAK-STAT cascade
GO:0060400 negative regulation of growth hormone receptor signaling pathway
GO:2000009 negative regulation of protein localization to cell surface
Cellular Component
GO:0000139 Golgi membrane
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035212
View Gene Order
ENSBTAG00000005909
Not yet available
Cross-References
SwissProt O15243
TrEMBL
UniProt Splice Variant
Entrez Gene 54741
UniGene Hs.23581 Hs.597113
RefSeq NM_001198681 NM_017526
HUGO HGNC:29477
OMIM 613461
CCDS CCDS630 CCDS72801
HPRD
IMGT
EMBL AC119800 AK074841 BC011027 BC056250 CH471059 CR541647 CR541737 Y12670
GenPept AAH11027 AAH56250 BAG52014 CAA73211 CAG46448 CAG46537 EAX06527 EAX06531
RNA Seq Atlas 54741

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca