InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SGIP1

Summary

InnateDB Protein

IDBP-99505.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SGIP1

Protein Name

SH3-domain GRB2-like (endophilin) interacting protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000360076

InnateDB Gene

IDBG-99495 (SGIP1)

Protein Structure

UniProt Annotation

Function

May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane, clathrin-coated pit {ECO:0000305PubMed:20946875}; Peripheral membrane protein {ECO:0000305PubMed:20946875}; Cytoplasmic side {ECO:0000305PubMed:20946875}.

Disease Associations

Tissue Specificity

Specifically expressed in brain. {ECO:0000269PubMed:15919751}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0017124	SH3 domain binding

Biological Process

GO:0002021	response to dietary excess
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0016192	vesicle-mediated transport
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0097320	membrane tubulation
GO:2000253	positive regulation of feeding behavior
GO:2000507	positive regulation of energy homeostasis

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0030122	AP-2 adaptor complex
GO:0030131	clathrin adaptor complex
GO:0030136	clathrin-coated vesicle