Version 5.4
Homo sapiens Gene: SGIP1
Summary
InnateDB Gene IDBG-99495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SGIP1
Gene Name SH3-domain GRB2-like (endophilin) interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000118473
Encoded Proteins
IDBP-99497
SH3-domain GRB2-like (endophilin) interacting protein 1
IDBP-99499
SH3-domain GRB2-like (endophilin) interacting protein 1
IDBP-99505
SH3-domain GRB2-like (endophilin) interacting protein 1
IDBP-385498
SH3-domain GRB2-like (endophilin) interacting protein 1
IDBP-385506
SH3-domain GRB2-like (endophilin) interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SGIP1 functions as an endocytic protein that affects signaling by receptors in neuronal systems involved in energy homeostasis via its interaction with endophilins (see SH3GL3; MIM 603362) (Trevaskis et al., 2005 [PubMed 15919751] and Uezu et al., 2007 [PubMed 17626015]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:66533383-66748299
Strand Forward strand
Band p31.3
Transcripts
ENST00000237247 ENSP00000237247
ENST00000371039 ENSP00000360078
ENST00000320161
ENST00000371037 ENSP00000360076
ENST00000424320 ENSP00000410439
ENST00000435165 ENSP00000395525
ENST00000493564
ENST00000468286
ENST00000497055
ENST00000484988
ENST00000483060
ENST00000480548
ENST00000487507
ENST00000468570
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0017124 SH3 domain binding
Biological Process
GO:0002021 response to dietary excess
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0016192 vesicle-mediated transport
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0097320 membrane tubulation
GO:2000253 positive regulation of feeding behavior
GO:2000507 positive regulation of energy homeostasis
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0030122 AP-2 adaptor complex
GO:0030131 clathrin adaptor complex
GO:0030136 clathrin-coated vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028524
View Gene Order
ENSBTAG00000011091
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.616028
RefSeq NM_032291 XM_005271264 XM_006710969
HUGO
OMIM
CCDS CCDS30744
HPRD 10910
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca