InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MIER1

Summary

InnateDB Protein

IDBP-99527.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MIER1

Protein Name

mesoderm induction early response 1 homolog (Xenopus laevis)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000360057

InnateDB Gene

IDBG-99523 (MIER1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269PubMed:12482978}.

Subcellular Localization

Isoform 1: Nucleus.Isoform 2: Nucleus.Isoform 3: Nucleus.Isoform 4: Cytoplasm.Isoform 5: Cytoplasm.Isoform 6: Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor. {ECO:0000269PubMed:12242014, ECO:0000269PubMed:9813250}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004871	signal transducer activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0031937	positive regulation of chromatin silencing
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling