InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC35D1

Summary

InnateDB Protein

IDBP-99544.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC35D1

Protein Name

solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1

Synonyms

UGTREL7;

Species

Homo sapiens

Ensembl Protein

ENSP00000235345

InnateDB Gene

IDBG-99542 (SLC35D1)

Protein Structure

UniProt Annotation

Function

Transports both UDP-glucuronic acid (UDP-GlcA) and UDP- N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm to into the endoplasmic reticulum lumen. May participate in glucuronidation and/or chondroitin sulfate biosynthesis.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Schneckenbecken dysplasia (SCHBCKD) [MIM:269250]: Rare, autosomal recessive, lethal short-limbed skeletal dysplasia with platyspondylia. {ECO:0000269PubMed:17952091}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005461	UDP-glucuronic acid transmembrane transporter activity
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity

Biological Process

GO:0006065	UDP-glucuronate biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0008643	carbohydrate transport
GO:0015781	pyrimidine nucleotide-sugar transport
GO:0015787	UDP-glucuronic acid transport
GO:0030206	chondroitin sulfate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0048706	embryonic skeletal system development
GO:0052695	cellular glucuronidation
GO:0055085	transmembrane transport
GO:0090481	pyrimidine nucleotide-sugar transmembrane transport