InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC35D1

Summary

InnateDB Gene

IDBG-99542.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC35D1

Gene Name

solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1

Synonyms

UGTREL7

Species

Homo sapiens

Ensembl Gene

ENSG00000116704

Encoded Proteins

IDBP-99544

solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glycosylation of cellular glycoconjugates occurs in the endoplasmic reticulum (ER) and Golgi compartment, and requires transport of nucleotide sugars from the cytosol into the lumen of the ER and Golgi by specific transporters. The protein encoded by this gene resides in the ER, and transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm to the ER lumen. It may participate in glucuronidation and/or chondroitin sulfate biosynthesis. Mutations in this gene are associated with Schneckenbecken dysplasia.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:66999332-67054099

Strand

Reverse strand

Band

p31.3

Transcripts

ENST00000235345

ENSP00000235345

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005461	UDP-glucuronic acid transmembrane transporter activity
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity

Biological Process

GO:0006065	UDP-glucuronate biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0008643	carbohydrate transport
GO:0015781	pyrimidine nucleotide-sugar transport
GO:0015787	UDP-glucuronic acid transport
GO:0030206	chondroitin sulfate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0048706	embryonic skeletal system development
GO:0052695	cellular glucuronidation
GO:0055085	transmembrane transport
GO:0090481	pyrimidine nucleotide-sugar transmembrane transport