InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WLS

Summary

InnateDB Protein

IDBP-99593.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WLS

Protein Name

wntless homolog (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346829

InnateDB Gene

IDBG-99591 (WLS)

Protein Structure

UniProt Annotation

Function

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:16678095}; Multi-pass membrane protein {ECO:0000269PubMed:16678095}. Cytoplasmic vesicle membrane {ECO:0000269PubMed:16678095}; Multi-pass membrane protein {ECO:0000269PubMed:16678095}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0031852	mu-type opioid receptor binding

Biological Process

GO:0001707	mesoderm formation
GO:0009948	anterior/posterior axis specification
GO:0016055	Wnt signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0031901	early endosome membrane
GO:0032590	dendrite membrane
GO:0032839	dendrite cytoplasm