InnateDB Protein
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IDBP-99595.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WLS
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Protein Name
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wntless homolog (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000262348
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InnateDB Gene
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IDBG-99591 (WLS)
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Protein Structure
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Function |
Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000269PubMed:16678095}; Multi-pass membrane protein {ECO:0000269PubMed:16678095}. Cytoplasmic vesicle membrane {ECO:0000269PubMed:16678095}; Multi-pass membrane protein {ECO:0000269PubMed:16678095}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0090263
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positive regulation of canonical Wnt signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5T9L3
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PhosphoSite |
PhosphoSite-Q5T9L3
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TrEMBL |
Q9H5T0
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UniProt Splice Variant |
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Entrez Gene |
79971
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UniGene |
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RefSeq |
NP_079187
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HUGO |
HGNC:30238
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OMIM |
611514
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CCDS |
CCDS642
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HPRD |
10980
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IMGT |
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EMBL |
AK026744
AK074984
AL157407
AL513284
AY359035
BC007211
BC110826
BC137109
BC137113
BX538320
BX648748
CH471059
DQ323735
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GenPept |
AAH07211
AAI10827
AAI37110
AAI37114
AAQ89394
ABD58927
BAB15540
BAC11333
CAD98094
CAI15024
CAI15025
CAI15027
CAI21993
EAX06480
EAX06481
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