Homo sapiens Protein: PTGER3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-99686.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PTGER3 | ||||||||||||||||||
Protein Name | prostaglandin E receptor 3 (subtype EP3) | ||||||||||||||||||
Synonyms | EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; PGE2-R; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000302313 | ||||||||||||||||||
InnateDB Gene | IDBG-99662 (PTGER3) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity). {ECO:0000250}. | ||||||||||||||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. {ECO:0000269PubMed:18023986}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000265
Prostanoid EP3 receptor IPR000276 G protein-coupled receptor, rhodopsin-like IPR001105 Thromboxane receptor IPR001244 Prostaglandin DP receptor IPR001481 Prostanoid EP3 receptor, type 2 IPR008365 Prostanoid receptor IPR017452 GPCR, rhodopsin-like, 7TM IPR019420 7TM GPCR, serpentine receptor class bc (Srbc) IPR019430 7TM GPCR, serpentine receptor class x (Srx) |
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PFAM |
PF00001
PF10316 PF10328 |
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PRINTS |
PR00582
PR00237 PR00429 PR00428 PR00584 PR01788 |
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PIRSF | |||||||||||||||||||
SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P43115 | ||||||||||||||||||
PhosphoSite | PhosphoSite-P43115 | ||||||||||||||||||
TrEMBL | Q9UBW3 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 5733 | ||||||||||||||||||
UniGene | Hs.595760 | ||||||||||||||||||
RefSeq | NP_942012 | ||||||||||||||||||
HUGO | HGNC:9595 | ||||||||||||||||||
OMIM | 176806 | ||||||||||||||||||
CCDS | CCDS657 | ||||||||||||||||||
HPRD | 08906 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB451481 AK315825 AL031429 AL158087 AY429108 BC024229 CH471059 D38297 D38298 D38299 D38300 D38301 D86096 D86098 EF534325 L26976 L27488 L27489 L27490 L32660 L32661 L32662 S68874 S69200 S69326 U13214 U13215 U13216 U13217 U13218 X83857 X83858 X83859 X83860 X83861 X83862 X83863 | ||||||||||||||||||
GenPept | AAA21130 AAA21131 AAA21132 AAA21133 AAA21134 AAA60076 AAA68191 AAA68192 AAA68193 AAB29854 AAB29855 AAB30208 AAC13372 AAC13373 AAC13374 AAH24229 AAR07903 ABS57464 BAA07416 BAA07417 BAA07418 BAA07419 BAA07420 BAA19951 BAA19952 BAA19954 BAA19956 BAA19957 BAA19959 BAF98716 BAG70295 CAA58737 CAA58738 CAA58739 CAA58740 CAA58741 CAA58742 CAA58743 CAB52459 CAI20226 CAI20227 CAI20228 CAI23437 EAX06439 EAX06446 | ||||||||||||||||||