InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WDR1

Summary

InnateDB Protein

IDBP-9974.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WDR1

Protein Name

WD repeat domain 1

Synonyms

AIP1; HEL-S-52; NORI-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000371889

InnateDB Gene

IDBG-9970 (WDR1)

Protein Structure

UniProt Annotation

Function

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, podosome {ECO:0000269PubMed:22721921}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0002576	platelet degranulation
GO:0007596	blood coagulation
GO:0007605	sensory perception of sound
GO:0030168	platelet activation

Cellular Component

GO:0002102	podosome
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030054	cell junction
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome