Version 5.4
Homo sapiens Gene: WDR1
Summary
InnateDB Gene IDBG-9970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR1
Gene Name WD repeat domain 1
Synonyms AIP1; HEL-S-52; NORI-1
Species Homo sapiens
Ensembl Gene ENSG00000071127
Encoded Proteins
IDBP-9972
WD repeat domain 1
IDBP-9974
WD repeat domain 1
IDBP-481785
WD repeat domain 1
IDBP-481370
WD repeat domain 1
IDBP-480582
WD repeat domain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:10074339-10116949
Strand Reverse strand
Band p16.1
Transcripts
ENST00000382452 ENSP00000371890
ENST00000382451 ENSP00000371889
ENST00000264785
ENST00000499869 ENSP00000427687
ENST00000502702 ENSP00000426725
ENST00000515743
ENST00000502962
ENST00000504739
ENST00000506246
ENST00000505543
ENST00000508949
ENST00000510848
ENST00000509695
ENST00000508079 ENSP00000425481
ENST00000505851
ENST00000514319
ENST00000515018
ENST00000509600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0002576 platelet degranulation
GO:0007596 blood coagulation
GO:0007605 sensory perception of sound
GO:0030168 platelet activation
GO:0048713 regulation of oligodendrocyte differentiation
Cellular Component
GO:0002102 podosome
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005884 actin filament
GO:0030054 cell junction
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005103
View Gene Order
ENSBTAG00000013607
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.128548
RefSeq NM_005112 NM_017491 XM_006713988
HUGO
OMIM
CCDS CCDS54739 CCDS54740
HPRD 09199
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca