InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FUBP1

Summary

InnateDB Protein

IDBP-99856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FUBP1

Protein Name

far upstream element (FUSE) binding protein 1

Synonyms

FBP; FUBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000359804

InnateDB Gene

IDBG-99850 (FUBP1)

Protein Structure

UniProt Annotation

Function

Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269PubMed:8125259}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.

Experimentally validated
Total	70 [view]
Protein-Protein	68 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0010628	positive regulation of gene expression
GO:0045944	positive regulation of transcription from RNA polymerase II promoter