InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTGFR

Summary

InnateDB Protein

IDBP-99871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGFR

Protein Name

prostaglandin F receptor (FP)

Synonyms

FP;

Species

Homo sapiens

Ensembl Protein

ENSP00000359793

InnateDB Gene

IDBG-99865 (PTGFR)

Protein Structure

UniProt Annotation

Function

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost. {ECO:0000250, ECO:0000269PubMed:18587449}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Eye. {ECO:0000269PubMed:18587449}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004958	prostaglandin F receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007567	parturition
GO:0032496	response to lipopolysaccharide
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000141 Prostaglandin F receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001105 Thromboxane receptor
IPR008365 Prostanoid receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019426 7TM GPCR, serpentine receptor class v (Srv)

PFAM

PF00001
PF10323

PRINTS

PR00855
PR00237
PR00429
PR01788

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P43088