Homo sapiens Gene: PTGFR
Summary
InnateDB Gene IDBG-99865.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGFR
Gene Name prostaglandin F receptor (FP)
Synonyms FP
Species Homo sapiens
Ensembl Gene ENSG00000122420
Encoded Proteins
prostaglandin F receptor (FP)
prostaglandin F receptor (FP)
prostaglandin F receptor (FP)
prostaglandin F receptor (FP)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:78303884-78539749
Strand Forward strand
Band p31.1
Transcripts
ENST00000370758 ENSP00000359794
ENST00000370756 ENSP00000359792
ENST00000370757 ENSP00000359793
ENST00000497923 ENSP00000432599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004958 prostaglandin F receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007567 parturition
GO:0032496 response to lipopolysaccharide
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Prostanoid ligand receptors pathway
Eicosanoid ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F2Z2Z6
UniProt Splice Variant
Entrez Gene 5737
UniGene Hs.552830 Hs.654365 Hs.709005
RefSeq NM_000959 NM_001039585 XM_006710781
HUGO HGNC:9600
OMIM 600563
CCDS CCDS30759 CCDS686
HPRD 08988
IMGT
EMBL AC096531 AL136324 AL158841
GenPept
RNA Seq Atlas 5737