InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKACB

Summary

InnateDB Protein

IDBP-99935.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKACB

Protein Name

protein kinase, cAMP-dependent, catalytic, beta

Synonyms

PKA C-beta; PKACB;

Species

Homo sapiens

Ensembl Protein

ENSP00000359722

InnateDB Gene

IDBG-99931 (PRKACB)

Protein Structure

UniProt Annotation

Function

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. {ECO:0000269PubMed:12420224, ECO:0000269PubMed:21423175}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21423175}. Cell membrane {ECO:0000269PubMed:21423175}. Nucleus {ECO:0000250}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain. {ECO:0000269PubMed:11589697}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004691	cAMP-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006112	energy reserve metabolic process
GO:0006468	protein phosphorylation
GO:0006833	water transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007268	synaptic transmission
GO:0007596	blood coagulation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0019433	triglyceride catabolic process
GO:0034199	activation of protein kinase A activity
GO:0035556	intracellular signal transduction
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050796	regulation of insulin secretion
GO:0055085	transmembrane transport
GO:0071377	cellular response to glucagon stimulus

Cellular Component

GO:0005654	nucleoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005952	cAMP-dependent protein kinase complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt