Version 5.4
Homo sapiens Gene: SORD
Summary
InnateDB Gene IDBG-10005.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORD
Gene Name sorbitol dehydrogenase
Synonyms HEL-S-95n; SORD1
Species Homo sapiens
Ensembl Gene ENSG00000140263
Encoded Proteins
IDBP-10007
sorbitol dehydrogenase
IDBP-600453
sorbitol dehydrogenase
IDBP-604048
sorbitol dehydrogenase
IDBP-583200
sorbitol dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:45023104-45077185
Strand Forward strand
Band q21.1
Transcripts
ENST00000267814 ENSP00000267814
ENST00000558789 ENSP00000453904
ENST00000559230 ENSP00000452731
ENST00000558580 ENSP00000453122
ENST00000560488
ENST00000559562
ENST00000558574
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003939 L-iditol 2-dehydrogenase activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0030246 carbohydrate binding
GO:0051287 NAD binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006060 sorbitol metabolic process
GO:0006062 sorbitol catabolic process
GO:0030317 sperm motility
GO:0046370 fructose biosynthetic process
GO:0051160 L-xylitol catabolic process
GO:0051164 L-xylitol metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0031514 motile cilium
GO:0031966 mitochondrial membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027227
View Gene Order
ENSBTAG00000025496
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00040
Pentose and glucuronate interconversions pathway
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.600174
RefSeq NM_003104
HUGO
OMIM
CCDS CCDS10116
HPRD 01679
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca