Homo sapiens Gene: SEP15
Summary
InnateDB Gene IDBG-100099.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEP15
Gene Name 15 kDa selenoprotein isoform 1 precursor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183291
Encoded Proteins
15 kDa selenoprotein
15 kDa selenoprotein
15 kDa selenoprotein
15 kDa selenoprotein isoform 1 precursor
15 kDa selenoprotein isoform 1 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies in mouse suggest that this selenoprotein may have redox function and may be involved in the quality control of protein folding. This gene is localized on chromosome 1p31, a genetic locus commonly mutated or deleted in human cancers. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3\' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies in mouse suggest that this selenoprotein may have redox function and may be involved in the quality control of protein folding. This gene is localized on chromosome 1p31, a genetic locus commonly mutated or deleted in human cancers. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:86862445-86914424
Strand Reverse strand
Band p22.3
Transcripts
ENST00000331835 ENSP00000328729
ENST00000370554 ENSP00000359585
ENST00000401030 ENSP00000383810
ENST00000469566
ENST00000497861
ENST00000467557
ENST00000616787 ENSP00000484190
ENST00000611507 ENSP00000481113
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008430 selenium binding
Biological Process
Cellular Component
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt
TrEMBL D3DT21
UniProt Splice Variant
Entrez Gene 9403
UniGene Hs.362728
RefSeq NM_004261 NM_203341
HUGO
OMIM 606254
CCDS
HPRD 09376
IMGT
EMBL CH471097
GenPept EAW73176 EAW73177
RNA Seq Atlas 9403