Version 5.4
Homo sapiens Gene: GBP1
Summary
InnateDB Gene IDBG-100165.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GBP1
Gene Name guanylate binding protein 1, interferon-inducible
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000117228
Encoded Proteins
IDBP-100167
guanylate binding protein 1, interferon-inducible
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:89052319-89065360
Strand Reverse strand
Band p22.2
Transcripts
ENST00000370473 ENSP00000359504
ENST00000484970
ENST00000479889
ENST00000468959
ENST00000495131
ENST00000459831
ENST00000493139
ENST00000469194
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 13 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0042802 identical protein binding
Biological Process
GO:0006184 GTP catabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_25078
Interferon gamma signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.443527
RefSeq NM_002053 XM_006710573
HUGO
OMIM
CCDS CCDS718
HPRD 02681
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca