Homo sapiens Gene: GBP1
Summary
InnateDB Gene IDBG-100165.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GBP1
Gene Name guanylate binding protein 1, interferon-inducible
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000117228
Encoded Proteins
guanylate binding protein 1, interferon-inducible
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:89052319-89065360
Strand Reverse strand
Band p22.2
Transcripts
ENST00000370473 ENSP00000359504
ENST00000484970
ENST00000479889
ENST00000468959
ENST00000495131
ENST00000459831
ENST00000493139
ENST00000469194
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 13 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0042802 identical protein binding
Biological Process
GO:0006184 GTP catabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
Interferon gamma signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.443527
RefSeq NM_002053 XM_006710573
HUGO
OMIM
CCDS CCDS718
HPRD 02681
IMGT
EMBL
GenPept
RNA Seq Atlas