InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GBP1

Summary

InnateDB Protein

IDBP-100167.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GBP1

Protein Name

guanylate binding protein 1, interferon-inducible

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000359504

InnateDB Gene

IDBG-100165 (GBP1)

Protein Structure

UniProt Annotation

Function

Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. {ECO:0000269PubMed:22106366}.

Subcellular Localization

Cytoplasm. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Secreted. Note=Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of interferon-gamma induction. Golgi membrane localization requires isoprenylation and the presence of another IFN-gamma-induced factor.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	13 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0042802	identical protein binding

Biological Process

GO:0006184	GTP catabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0051607	defense response to virus
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR003191 Guanylate-binding protein, C-terminal
IPR015894 Guanylate-binding protein, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02841
PF02263

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32455

PhosphoSite