Version 5.4
Homo sapiens Gene: FNBP1L
Summary
InnateDB Gene IDBG-100334.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FNBP1L
Gene Name formin binding protein 1-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137942
Encoded Proteins
IDBP-100338
formin binding protein 1-like
IDBP-100340
formin binding protein 1-like
IDBP-100342
formin binding protein 1-like
IDBP-386862
formin binding protein 1-like
IDBP-807394
formin binding protein 1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:93448131-93554661
Strand Forward strand
Band p22.1
Transcripts
ENST00000370253 ENSP00000359275
ENST00000271234 ENSP00000271234
ENST00000260506 ENSP00000260506
ENST00000424449 ENSP00000397451
ENST00000604705 ENSP00000473921
ENST00000603526
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0006900 membrane budding
GO:0006914 autophagy
GO:0007165 signal transduction
GO:0010324 membrane invagination
GO:0016050 vesicle organization
GO:0030050 vesicle transport along actin filament
GO:0051491 positive regulation of filopodium assembly
GO:0072583 clathrin-mediated endocytosis
GO:0097320 membrane tubulation
Cellular Component
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039735
View Gene Order
ENSBTAG00000004383
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.743249
RefSeq NM_001024948 NM_001164473 NM_017737 XM_006710707
HUGO
OMIM
CCDS CCDS53343 CCDS53344 CCDS60192
HPRD 12317
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca