InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GCLM

Summary

InnateDB Gene

IDBG-100355.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCLM

Gene Name

glutamate-cysteine ligase, modifier subunit

Synonyms

GLCLR

Species

Homo sapiens

Ensembl Gene

ENSG00000023909

Encoded Proteins

IDBP-100357

glutamate-cysteine ligase, modifier subunit

IDBP-811207

glutamate-cysteine ligase, modifier subunit

IDBP-811208

glutamate-cysteine ligase, modifier subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:93885205-93909456

Strand

Reverse strand

Band

p22.1

Transcripts

ENST00000370238	ENSP00000359258
ENST00000467772
ENST00000462183
ENST00000619076	ENSP00000478170
ENST00000615724	ENSP00000484507

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004357	glutamate-cysteine ligase activity
GO:0035226	glutamate-cysteine ligase catalytic subunit binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006534	cysteine metabolic process
GO:0006536	glutamate metabolic process
GO:0006749	glutathione metabolic process
GO:0006750	glutathione biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0006979	response to oxidative stress
GO:0008637	apoptotic mitochondrial changes
GO:0034641	cellular nitrogen compound metabolic process
GO:0035229	positive regulation of glutamate-cysteine ligase activity
GO:0042493	response to drug
GO:0043524	negative regulation of neuron apoptotic process
GO:0044281	small molecule metabolic process
GO:0050880	regulation of blood vessel size
GO:0051409	response to nitrosative stress
GO:0051900	regulation of mitochondrial depolarization
GO:1901687	glutathione derivative biosynthetic process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0017109	glutamate-cysteine ligase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028124

View Gene Order

ENSBTAG00000007842

Not yet available

Pathways

NETPATH

REACTOME

REACT_115639

Sulfur amino acid metabolism pathway

REACT_6960

Glutathione synthesis and recycling pathway

REACT_6926

Glutathione conjugation pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_6959

Phase II conjugation pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

KEGG

hsa00480

Glutathione metabolism pathway

INOH

INOH website

Glutamate Glutamine metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.315562 Hs.606719 Hs.711318

RefSeq

NM_002061 XM_005270754

HUGO

OMIM

CCDS

CCDS746

HPRD

03106

IMGT

EMBL

GenPept

RNA Seq Atlas