InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCLM

Summary

InnateDB Protein

IDBP-100357.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCLM

Protein Name

glutamate-cysteine ligase, modifier subunit

Synonyms

GLCLR;

Species

Homo sapiens

Ensembl Protein

ENSP00000359258

InnateDB Gene

IDBG-100355 (GCLM)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

In all tissues examined. Highest levels in skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004357	glutamate-cysteine ligase activity
GO:0035226	glutamate-cysteine ligase catalytic subunit binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006534	cysteine metabolic process
GO:0006536	glutamate metabolic process
GO:0006749	glutathione metabolic process
GO:0006750	glutathione biosynthetic process
GO:0006805	xenobiotic metabolic process
GO:0006979	response to oxidative stress
GO:0008637	apoptotic mitochondrial changes
GO:0034641	cellular nitrogen compound metabolic process
GO:0035229	positive regulation of glutamate-cysteine ligase activity
GO:0042493	response to drug
GO:0043524	negative regulation of neuron apoptotic process
GO:0044281	small molecule metabolic process
GO:0050880	regulation of blood vessel size
GO:0051409	response to nitrosative stress
GO:0051900	regulation of mitochondrial depolarization
GO:1901687	glutathione derivative biosynthetic process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway