Version 5.4
Homo sapiens Gene: PTBP2
Summary
InnateDB Gene IDBG-100408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTBP2
Gene Name polypyrimidine tract binding protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000117569
Encoded Proteins
IDBP-100412
polypyrimidine tract binding protein 2
IDBP-100414
polypyrimidine tract binding protein 2
IDBP-387014
polypyrimidine tract binding protein 2
IDBP-806615
polypyrimidine tract binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein but it is expressed primarily in the brain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:96721665-96823738
Strand Forward strand
Band p21.3
Transcripts
ENST00000370197 ENSP00000359216
ENST00000370198 ENSP00000359217
ENST00000426398 ENSP00000412788
ENST00000482253
ENST00000460706
ENST00000476419
ENST00000459735
ENST00000476783
ENST00000492905
ENST00000462433
ENST00000609116 ENSP00000477024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006376 mRNA splice site selection
GO:0006397 mRNA processing
GO:0033119 negative regulation of RNA splicing
GO:2000177 regulation of neural precursor cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000028134
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9UKA9
TrEMBL
UniProt Splice Variant
Entrez Gene 58155
UniGene Hs.743449
RefSeq NM_021190 NM_001300985 NM_001300986 NM_001300988 NM_001300989 NM_001300990 XM_005271084 XM_005271085 XM_005271086
HUGO HGNC:17662
OMIM 608449
CCDS CCDS754 CCDS72828 CCDS72829 CCDS72830
HPRD 12233
IMGT
EMBL AB051232 AB051233 AF176085 AF530580 AF530581 AF530582 AF530583 AL357150 BC016582 BK000526
GenPept AAF14284 AAH16582 AAM94624 AAM94625 AAM94626 AAM94627 BAB71742 BAB71743 CAH70266 CAH70267 CAH70268 CAH70269 DAA00060
RNA Seq Atlas 58155

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca