InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CELSR2

Summary

InnateDB Gene

IDBG-100797.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CELSR2

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

Synonyms

CDHF10; EGFL2; Flamingo1; MEGF3

Species

Homo sapiens

Ensembl Gene

ENSG00000143126

Encoded Proteins

IDBP-100799

cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:109250019-109275750

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000271332	ENSP00000271332
ENST00000459940
ENST00000489018
ENST00000498157

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0003341	cilium movement
GO:0006355	regulation of transcription, DNA-templated
GO:0007156	homophilic cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0016055	Wnt signaling pathway
GO:0021591	ventricular system development
GO:0021999	neural plate anterior/posterior regionalization
GO:0022407	regulation of cell-cell adhesion
GO:0032880	regulation of protein localization
GO:0033326	cerebrospinal fluid secretion
GO:0042384	cilium assembly
GO:0048813	dendrite morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000068740

View Gene Order

ENSBTAG00000018804

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.57652 Hs.605736 Hs.622491

RefSeq

NM_001408

HUGO

OMIM

CCDS

CCDS796

HPRD

05040

IMGT

EMBL

GenPept

RNA Seq Atlas