InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CELSR2

Summary

InnateDB Protein

IDBP-100799.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CELSR2

Protein Name

cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)

Synonyms

CDHF10; EGFL2; Flamingo1; MEGF3;

Species

Homo sapiens

Ensembl Protein

ENSP00000271332

InnateDB Gene

IDBG-100797 (CELSR2)

Protein Structure

UniProt Annotation

Function

Receptor that may have an important role in cell/cell signaling during nervous system formation.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highest expression in brain and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0003341	cilium movement
GO:0006355	regulation of transcription, DNA-templated
GO:0007156	homophilic cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0016055	Wnt signaling pathway
GO:0021591	ventricular system development
GO:0021999	neural plate anterior/posterior regionalization
GO:0022407	regulation of cell-cell adhesion
GO:0032880	regulation of protein localization
GO:0033326	cerebrospinal fluid secretion
GO:0042384	cilium assembly
GO:0048813	dendrite morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000203 GPS motif
IPR000742 Epidermal growth factor-like domain
IPR000832 GPCR, family 2, secretin-like
IPR001791 Laminin G domain
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR001881 EGF-like calcium-binding domain
IPR002049 EGF-like, laminin
IPR002126 Cadherin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR015919 Cadherin-like
IPR017981 GPCR, family 2-like
IPR022624 Domain of unknown function DUF3497

PFAM