Version 5.4
Homo sapiens Gene: ALX3
Summary
InnateDB Gene IDBG-100947.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALX3
Gene Name ALX homeobox 3
Synonyms FND; FND1
Species Homo sapiens
Ensembl Gene ENSG00000156150
Encoded Proteins
IDBP-100949
ALX homeobox 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]
This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene\'s promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:110059994-110070700
Strand Reverse strand
Band p13.3
Transcripts
ENST00000369792 ENSP00000358807
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007389 pattern specification process
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0042981 regulation of apoptotic process
GO:0048704 embryonic skeletal system morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014603
View Gene Order
ENSBTAG00000020966
Not yet available
Cross-References
SwissProt O95076
TrEMBL
UniProt Splice Variant
Entrez Gene 257
UniGene
RefSeq NM_006492
HUGO HGNC:449
OMIM 606014
CCDS CCDS819
HPRD
IMGT
EMBL AF008202 AF008203 AL160006 BC112007 BC113428 CH471122
GenPept AAD01417 AAD01418 AAI12008 AAI13429 CAI22714 EAW56430
RNA Seq Atlas 257

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca