Homo sapiens Gene: OVGP1
Summary
InnateDB Gene IDBG-101056.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OVGP1
Gene Name oviductal glycoprotein 1, 120kDa
Synonyms CHIT5; EGP; MUC9; OGP;
Species Homo sapiens
Ensembl Gene ENSG00000085465
Encoded Proteins
oviductal glycoprotein 1, 120kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:111414314-111427777
Strand Reverse strand
Band p13.2
Transcripts
ENST00000369732 ENSP00000358747
ENST00000494622
ENST00000481495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568 chitinase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006032 chitin catabolic process
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0007565 female pregnancy
GO:0032504 multicellular organism reproduction
GO:2000360 negative regulation of binding of sperm to zona pellucida
Cellular Component
GO:0005829 cytosol
GO:0030133 transport vesicle
GO:0035805 egg coat
GO:0098595 perivitelline space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Interaction With The Zona Pellucida pathway
Fertilization pathway
Reproduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q12889
TrEMBL Q9UJZ3
UniProt Splice Variant
Entrez Gene 5016
UniGene
RefSeq NM_002557
HUGO HGNC:8524
OMIM 603578
CCDS CCDS834
HPRD
IMGT
EMBL AF189710 AL390195 BC126177 BC136406 U09550 U58001 U58002 U58003 U58004 U58005 U58006 U58007 U58008 U58009 U58010
GenPept AAA86946 AAB04126 AAF01065 AAI26178 AAI36407 CAC36039
RNA Seq Atlas 5016