Version 5.4
Homo sapiens Gene: OVGP1
Summary
InnateDB Gene IDBG-101056.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OVGP1
Gene Name oviductal glycoprotein 1, 120kDa
Synonyms CHIT5; EGP; MUC9; OGP
Species Homo sapiens
Ensembl Gene ENSG00000085465
Encoded Proteins
IDBP-101058
oviductal glycoprotein 1, 120kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:111414314-111427777
Strand Reverse strand
Band p13.2
Transcripts
ENST00000369732 ENSP00000358747
ENST00000494622
ENST00000481495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568 chitinase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006032 chitin catabolic process
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0007565 female pregnancy
GO:0032504 multicellular organism reproduction
GO:2000360 negative regulation of binding of sperm to zona pellucida
Cellular Component
GO:0005829 cytosol
GO:0030133 transport vesicle
GO:0035805 egg coat
GO:0098595 perivitelline space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000074340
View Gene Order
ENSBTAG00000024849
Not yet available
Pathways
NETPATH
REACTOME
REACT_163933
Interaction With The Zona Pellucida pathway
REACT_163914
Fertilization pathway
REACT_163848
Reproduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002557
HUGO
OMIM
CCDS CCDS834
HPRD 04658
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca