InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OVGP1

Summary

InnateDB Protein

IDBP-101058.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OVGP1

Protein Name

oviductal glycoprotein 1, 120kDa

Synonyms

CHIT5; EGP; MUC9; OGP;

Species

Homo sapiens

Ensembl Protein

ENSP00000358747

InnateDB Gene

IDBG-101056 (OVGP1)

Protein Structure

UniProt Annotation

Function

Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules.

Disease Associations

Tissue Specificity

Oviduct.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568	chitinase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006032	chitin catabolic process
GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida
GO:0007565	female pregnancy
GO:0032504	multicellular organism reproduction
GO:2000360	negative regulation of binding of sperm to zona pellucida

Cellular Component

GO:0005829	cytosol
GO:0030133	transport vesicle
GO:0035805	egg coat
GO:0098595	perivitelline space

Protein Structure and Domains

PDB ID

InterPro

IPR001223 Glycoside hydrolase, family 18, catalytic domain
IPR011583 Chitinase II
IPR017853 Glycoside hydrolase, superfamily
IPR029070 Chitinase insertion domain

PFAM

PF00704

PRINTS

PIRSF

SMART

SM00636

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q12889