Version 5.4
Homo sapiens Gene: MAN1A2
Summary
InnateDB Gene IDBG-101453.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAN1A2
Gene Name mannosidase, alpha, class 1A, member 2
Synonyms MAN1B
Species Homo sapiens
Ensembl Gene ENSG00000198162
Encoded Proteins
IDBP-101457
mannosidase, alpha, class 1A, member 2
IDBP-387900
mannosidase, alpha, class 1A, member 2
IDBP-387901
mannosidase, alpha, class 1A, member 2
IDBP-387902
mannosidase, alpha, class 1A, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:117367449-117528872
Strand Forward strand
Band p12
Transcripts
ENST00000356554 ENSP00000348959
ENST00000449370 ENSP00000412706
ENST00000421535 ENSP00000396362
ENST00000422329 ENSP00000402416
ENST00000482811
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006491 N-glycan processing
GO:0007585 respiratory gaseous exchange
GO:0008152 metabolic process
GO:0009100 glycoprotein metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048286 lung alveolus development
Cellular Component
GO:0000139 Golgi membrane
GO:0005730 nucleolus
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000008763
View Gene Order
ENSBTAG00000003586
Not yet available
Pathways
NETPATH
REACTOME
REACT_25396
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 pathway
REACT_25210
N-glycan trimming and elongation in the cis-Golgi pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt O60476
TrEMBL
UniProt Splice Variant
Entrez Gene 10905
UniGene Hs.435938 Hs.595305 Hs.602811 Hs.715929
RefSeq NM_006699
HUGO HGNC:6822
OMIM 604345
CCDS CCDS895
HPRD 05067
IMGT
EMBL AF027156 AF053615 AF053616 AF053617 AF053618 AF053619 AF053620 AF053621 AF053622 AF053623 AF053624 AF053625 AF053626 AL157902 AL358072 BC063300
GenPept AAC26169 AAC26200 AAC26201 AAH63300 CAH71079 CAI22315
RNA Seq Atlas 10905

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca