InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAN1A2

Summary

InnateDB Protein

IDBP-101457.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAN1A2

Protein Name

mannosidase, alpha, class 1A, member 2

Synonyms

MAN1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000348959

InnateDB Gene

IDBG-101453 (MAN1A2)

Protein Structure

UniProt Annotation

Function

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).

Subcellular Localization

Golgi apparatus membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Highest levels of expression in placenta and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509	calcium ion binding

Biological Process

GO:0006491	N-glycan processing
GO:0007585	respiratory gaseous exchange
GO:0009100	glycoprotein metabolic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0048286	lung alveolus development

Cellular Component

GO:0000139	Golgi membrane
GO:0005730	nucleolus
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome