Version 5.4
Homo sapiens Gene: HSD3B1
Summary
InnateDB Gene IDBG-101508.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSD3B1
Gene Name hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Synonyms 3BETAHSD; HSD3B; HSDB3; HSDB3A; I; SDR11E1
Species Homo sapiens
Ensembl Gene ENSG00000203857
Encoded Proteins
IDBP-101510
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IDBP-597894
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IDBP-593150
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:119507198-119515054
Strand Forward strand
Band p12
Transcripts
ENST00000369413 ENSP00000358421
ENST00000492140
ENST00000487520
ENST00000531340 ENSP00000435999
ENST00000528909 ENSP00000432268
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004769 steroid delta-isomerase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050662 coenzyme binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0006702 androgen biosynthetic process
GO:0006703 estrogen biosynthetic process
GO:0006704 glucocorticoid biosynthetic process
GO:0006705 mineralocorticoid biosynthetic process
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0009058 biosynthetic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0030868 smooth endoplasmic reticulum membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_11036
Glucocorticoid biosynthesis pathway
REACT_11047
Mineralocorticoid biosynthesis pathway
REACT_11059
Androgen biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111217
Metabolism pathway
KEGG
hsa00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000862
HUGO
OMIM
CCDS CCDS903
HPRD 04920
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca