InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSD3B1

Summary

InnateDB Protein

IDBP-101510.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSD3B1

Protein Name

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Synonyms

3BETAHSD; HSD3B; HSDB3; HSDB3A; I; SDR11E1;

Species

Homo sapiens

Ensembl Protein

ENSP00000358421

InnateDB Gene

IDBG-101508 (HSD3B1)

Protein Structure

UniProt Annotation

Function

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. {ECO:0000269PubMed:1401999, ECO:0000269PubMed:2139411}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Placenta and skin. Predominantly expressed in mammary gland tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004769	steroid delta-isomerase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050662	coenzyme binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0006702	androgen biosynthetic process
GO:0006703	estrogen biosynthetic process
GO:0006704	glucocorticoid biosynthetic process
GO:0006705	mineralocorticoid biosynthetic process
GO:0008152	metabolic process
GO:0008202	steroid metabolic process
GO:0009058	biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0030868	smooth endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR008030 NmrA-like domain
IPR013120 Male sterility, NAD-binding
IPR013968 Polyketide synthase, KR

PFAM