InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NOTCH2

Summary

InnateDB Gene

IDBG-101546.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOTCH2

Gene Name

notch 2

Synonyms

AGS2; HJCYS; hN2

Species

Homo sapiens

Ensembl Gene

ENSG00000134250

Encoded Proteins

IDBP-101548

notch 2

IDBP-813222

notch 2

IDBP-813223

notch 2

IDBP-813227

notch 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:119911553-120069626

Strand

Reverse strand

Band

p12

Transcripts

ENST00000256646	ENSP00000256646
ENST00000493703
ENST00000478864
ENST00000479412
ENST00000489731
ENST00000602566	ENSP00000473427
ENST00000612822	ENSP00000479088
ENST00000579475	ENSP00000477065

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0038049	ligand-activated RNA polymerase II transcription factor binding transcription factor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001709	cell fate determination
GO:0001890	placenta development
GO:0002011	morphogenesis of an epithelial sheet
GO:0002437	inflammatory response to antigenic stimulus
GO:0003184	pulmonary valve morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0006959	humoral immune response
GO:0007050	cell cycle arrest
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007275	multicellular organismal development
GO:0007368	determination of left/right symmetry
GO:0007399	nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0010467	gene expression
GO:0016049	cell growth
GO:0019827	stem cell maintenance
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030326	embryonic limb morphogenesis
GO:0030513	positive regulation of BMP signaling pathway
GO:0030522	intracellular receptor signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0046579	positive regulation of Ras protein signal transduction
GO:0046849	bone remodeling
GO:0050793	regulation of developmental process
GO:0060413	atrial septum morphogenesis
GO:0060674	placenta blood vessel development
GO:0061073	ciliary body morphogenesis
GO:0061314	Notch signaling involved in heart development
GO:0072602	interleukin-4 secretion

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005929	cilium
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex