Version 5.4
Homo sapiens Gene: ITGA10
Summary
InnateDB Gene IDBG-101745.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGA10
Gene Name integrin, alpha 10
Synonyms PRO827
Species Homo sapiens
Ensembl Gene ENSG00000143127
Encoded Proteins
IDBP-101747
integrin, alpha 10
IDBP-591411
integrin, alpha 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:145891208-145910189
Strand Reverse strand
Band q21.1
Transcripts
ENST00000369304 ENSP00000358310
ENST00000468261
ENST00000481236
ENST00000539363 ENSP00000439894
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005518 collagen binding
GO:0046872 metal ion binding
Biological Process
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000090210
View Gene Order
ENSBTAG00000008373
Not yet available
Pathways
NETPATH
REACTOME
REACT_1230
Platelet Adhesion to exposed collagen pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_22292
CHL1 interactions pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_118779
Extracellular matrix organization pathway
REACT_18266
Axon guidance pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_cs_pathway
Integrin family cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.158237
RefSeq NM_003637 XM_005277432 XM_005277435 XM_005277436 XM_006711596
HUGO
OMIM
CCDS CCDS72869
HPRD 04952
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca