InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA10

Summary

InnateDB Protein

IDBP-101747.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA10

Protein Name

integrin, alpha 10

Synonyms

PRO827;

Species

Homo sapiens

Ensembl Protein

ENSP00000358310

InnateDB Gene

IDBG-101745 (ITGA10)

Protein Structure

UniProt Annotation

Function

Integrin alpha-10/beta-1 is a receptor for collagen.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Widely expressed with highest expression in muscle and heart. Found in articular cartilage.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005518	collagen binding
GO:0046872	metal ion binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005886	plasma membrane
GO:0008305	integrin complex

Protein Structure and Domains

PDB ID

InterPro

IPR000413 Integrin alpha chain
IPR002035 von Willebrand factor, type A
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2

PFAM

PF00092
PF01839
PF14312
PF08441

PRINTS

PR01185

PIRSF

SMART

SM00327
SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt