Homo sapiens Gene: FCGR1A | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-101961.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | FCGR1A | ||||||||||||||||||||||
Gene Name | Fc fragment of IgG, high affinity Ia, receptor (CD64) | ||||||||||||||||||||||
Synonyms | CD64; CD64A; FCRI; IGFR1 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000150337 | ||||||||||||||||||||||
Encoded Proteins |
Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ia, receptor (CD64)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
FCGR1A (FcgammaRI) is a receptor that recognizes IgG opsonized particles and initiates phagocytosis in immune clearance. FCGR1A is also a negative regulator of complement-mediated phagocytosis.
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Entrez Gene | |||||||||||||||||||||||
Summary |
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008] This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 1:149782671-149792518 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q21.2 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Cross-presentation of soluble exogenous antigens (endosomes) pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Role of phospholipids in phagocytosis pathway
FCGR activation pathway
Interferon gamma signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Interferon Signaling pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Class I MHC mediated antigen processing & presentation pathway
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KEGG |
Hematopoietic cell lineage pathway
Systemic lupus erythematosus pathway
Fc gamma R-mediated phagocytosis pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Osteoclast differentiation pathway
Phagosome pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | C9JSN8 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 2209 | ||||||||||||||||||||||
UniGene | Hs.635062 Hs.739894 Hs.77424 | ||||||||||||||||||||||
RefSeq | NM_000566 XM_005244957 XM_005244958 | ||||||||||||||||||||||
HUGO | HGNC:3613 | ||||||||||||||||||||||
OMIM | 146760 | ||||||||||||||||||||||
CCDS | CCDS933 | ||||||||||||||||||||||
HPRD | 00904 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AL591493 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 2209 | ||||||||||||||||||||||