|Homo sapiens Gene: CTSS|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||cathepsin S|
|Useful resources||Stemformatics EHFPI ImmGen|
CTSS is a member of the Cathepsins protein family, which are key modulators of cell death and inflammatory responses.
CTSS is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. TLR2, 3, 4 ligand engagement increases the proteolytic activities of CTSS in macrophages. (Demonstrated in murine model)
Cleavage of CAMP by cathepsins CTSS and CTSK impairs its antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus.
|InnateDB Annotation from Orthologs|
[Mus musculus] Ctss is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. Tlr2, 3, 4 ligand engagement increases the proteolytic activities of Ctss in macrophages.
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
|Genomic Location||Chromosome 1:150730196-150765957|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
MHC class II antigen presentation pathway
Extracellular matrix organization pathway
Innate Immune System pathway
Endosomal/Vacuolar pathway pathway
Degradation of the extracellular matrix pathway
Toll-Like Receptors Cascades pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Trafficking and processing of endosomal TLR pathway
Assembly of collagen fibrils and other multimeric structures pathway
Class I MHC mediated antigen processing & presentation pathway
Collagen formation pathway
Antigen processing and presentation pathway
|UniProt Splice Variant|
|RNA Seq Atlas|