InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CTSS

Summary

InnateDB Gene

IDBG-102189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSS

Gene Name

cathepsin S

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000163131

Encoded Proteins

IDBP-102191

cathepsin S

IDBP-388389

cathepsin S

IDBP-809476

cathepsin S

IDBP-809481

cathepsin S

IDBP-809478

cathepsin S

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18762176

CTSS is a member of the Cathepsins protein family, which are key modulators of cell death and inflammatory responses.

PMID 21145045

CTSS is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. TLR2, 3, 4 ligand engagement increases the proteolytic activities of CTSS in macrophages. (Demonstrated in murine model)

PMID 25884905

Cleavage of CAMP by cathepsins CTSS and CTSK impairs its antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus.

InnateDB Annotation from Orthologs

Summary

PMID 21145045

[Mus musculus] Ctss is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. Tlr2, 3, 4 ligand engagement increases the proteolytic activities of Ctss in macrophages.

Entrez Gene

Summary

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:150730196-150765957

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000368985	ENSP00000357981
ENST00000448301	ENSP00000408414
ENST00000472977	ENSP00000475176
ENST00000483930	ENSP00000475812
ENST00000480760
ENST00000607427	ENSP00000475557

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0004197	cysteine-type endopeptidase activity
GO:0005518	collagen binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0043236	laminin binding
GO:0043394	proteoglycan binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002250	adaptive immune response
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0006508	proteolysis
GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0034769	basement membrane disassembly
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087	innate immune response (InnateDB)
GO:0050729	positive regulation of inflammatory response
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0097067	cellular response to thyroid hormone stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005764	lysosome
GO:0016020	membrane
GO:0036021	endolysosome lumen
GO:0043202	lysosomal lumen
GO:0043231	intracellular membrane-bounded organelle