Homo sapiens Gene: CTSS
Summary
InnateDB Gene IDBG-102189.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSS
Gene Name cathepsin S
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163131
Encoded Proteins
cathepsin S
cathepsin S
cathepsin S
cathepsin S
cathepsin S
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CTSS is a member of the Cathepsins protein family, which are key modulators of cell death and inflammatory responses.
CTSS is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. TLR2, 3, 4 ligand engagement increases the proteolytic activities of CTSS in macrophages. (Demonstrated in murine model)
Cleavage of CAMP by cathepsins CTSS and CTSK impairs its antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Ctss is an endosomal and lysosomal protease that is upregulated during various inflammatory disorders. Tlr2, 3, 4 ligand engagement increases the proteolytic activities of Ctss in macrophages.
Entrez Gene
Summary The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:150730196-150765957
Strand Reverse strand
Band q21.3
Transcripts
ENST00000368985 ENSP00000357981
ENST00000448301 ENSP00000408414
ENST00000472977 ENSP00000475176
ENST00000483930 ENSP00000475812
ENST00000480760
ENST00000607427 ENSP00000475557
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0004197 cysteine-type endopeptidase activity
GO:0005518 collagen binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0043236 laminin binding
GO:0043394 proteoglycan binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0006508 proteolysis
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0034769 basement membrane disassembly
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087 innate immune response (InnateDB)
GO:0050729 positive regulation of inflammatory response
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0097067 cellular response to thyroid hormone stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0016020 membrane
GO:0036021 endolysosome lumen
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
Extracellular matrix organization pathway
Innate Immune System pathway
Endosomal/Vacuolar pathway pathway
Degradation of the extracellular matrix pathway
Toll-Like Receptors Cascades pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Trafficking and processing of endosomal TLR pathway
Assembly of collagen fibrils and other multimeric structures pathway
Class I MHC mediated antigen processing & presentation pathway
Collagen formation pathway
KEGG
Lysosome pathway
Phagosome pathway
Antigen processing and presentation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.181301 Hs.732675
RefSeq NM_001199739 NM_004079
HUGO
OMIM
CCDS CCDS55634 CCDS968
HPRD 00292
IMGT
EMBL
GenPept
RNA Seq Atlas