Homo sapiens Gene: PIP5K1A
Summary
InnateDB Gene IDBG-102321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIP5K1A
Gene Name phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143398
Encoded Proteins
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:151197949-151249536
Strand Forward strand
Band q21.3
Transcripts
ENST00000349792 ENSP00000271663
ENST00000368890 ENSP00000357885
ENST00000368888 ENSP00000357883
ENST00000409426 ENSP00000386432
ENST00000447555 ENSP00000401228
ENST00000454769 ENSP00000416196
ENST00000441902 ENSP00000415648
ENST00000424999 ENSP00000392780
ENST00000418435 ENSP00000414632
ENST00000468772
ENST00000461816
ENST00000481713
ENST00000486048
ENST00000464105
ENST00000486866
ENST00000460157
ENST00000489625
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 12 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016307 phosphatidylinositol phosphate kinase activity
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0019900 kinase binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006909 phagocytosis
GO:0007165 signal transduction
GO:0008654 phospholipid biosynthetic process
GO:0010761 fibroblast migration
GO:0016477 cell migration
GO:0030216 keratinocyte differentiation
GO:0031532 actin cytoskeleton reorganization
GO:0032863 activation of Rac GTPase activity
GO:0044281 small molecule metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046854 phosphatidylinositol phosphorylation
GO:0048041 focal adhesion assembly
GO:0060326 cell chemotaxis
GO:0072661 protein targeting to plasma membrane
GO:0097178 ruffle assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
GO:0005886 plasma membrane
GO:0016607 nuclear speck
GO:0030027 lamellipodium
GO:0032587 ruffle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
BCR pathway
REACTOME
Metabolism of lipids and lipoproteins pathway
Synthesis of PIPs at the plasma membrane pathway
PI Metabolism pathway
Phospholipid metabolism pathway
Metabolism pathway
KEGG
Inositol phosphate metabolism pathway
Phosphatidylinositol signaling system pathway
Endocytosis pathway
Fc gamma R-mediated phagocytosis pathway
Regulation of actin cytoskeleton pathway
INOH
Inositol phosphate metabolism pathway
PID BIOCARTA
Rho cell motility signaling pathway [Biocarta view]
PID NCI
Arf1 pathway
RAC1 signaling pathway
Arf6 downstream pathway
E-cadherin signaling in keratinocytes
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.600845 Hs.661888 Hs.676966 Hs.707446 Hs.731305
RefSeq NM_001135636 NM_001135637 NM_001135638 NM_003557 XM_005245530 XM_005245531 XM_006711566 XM_006711567 XM_006711568
HUGO
OMIM
CCDS CCDS44219 CCDS44220 CCDS44221 CCDS990
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas