Version 5.4
Homo sapiens Gene: TUFT1
Summary
InnateDB Gene IDBG-102387.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUFT1
Gene Name tuftelin 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143367
Encoded Proteins
IDBP-102389
tuftelin 1
IDBP-102391
tuftelin 1
IDBP-102393
tuftelin 1
IDBP-245094
tuftelin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:151540305-151583583
Strand Forward strand
Band q21.3
Transcripts
ENST00000368849 ENSP00000357842
ENST00000368848 ENSP00000357841
ENST00000353024 ENSP00000343781
ENST00000392712 ENSP00000376476
ENST00000498606
ENST00000461859
ENST00000490156
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030345 structural constituent of tooth enamel
Biological Process
GO:0030282 bone mineralization
GO:0042476 odontogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005968
View Gene Order
ENSBTAG00000017566
Not yet available
Cross-References
SwissProt Q9NNX1
TrEMBL A6PVU8 Q6UWW7
UniProt Splice Variant
Entrez Gene 7286
UniGene Hs.489922
RefSeq NM_001126337 NM_001301317 NM_020127 XM_005245474
HUGO HGNC:12422
OMIM 600087
CCDS CCDS1000 CCDS44223
HPRD
IMGT
EMBL AF254260 AF254850 AF254851 AF254852 AF254854 AF254855 AF254856 AF254857 AF254858 AF254859 AF254860 AK026989 AK075001 AK315414 AL136917 AL365436 AY358610 BC002933 BC008301 CH471121
GenPept AAF78913 AAF78914 AAH02933 AAH08301 AAQ88973 BAB15615 BAC11346 BAG37804 CAB66851 CAI16591 CAI16592 EAW53429 EAW53430 EAW53431 EAW53433
RNA Seq Atlas 7286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca