Version 5.4
Homo sapiens Protein: TUFT1
Summary
InnateDB Protein IDBP-102389.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUFT1
Protein Name tuftelin 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357842
InnateDB Gene IDBG-102387 (TUFT1)
Protein Structure
UniProt Annotation
Function Involved in the mineralization and structural organization of enamel.
Subcellular Localization Secreted {ECO:0000250}. Note=Secreted at a very early stage of enamel formation, concentrated at the dentin- enamel junction and tightly bound to the surface of the growing crystallites. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030345 structural constituent of tooth enamel
Biological Process
GO:0030282 bone mineralization
GO:0042476 odontogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR009053 Prefoldin
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NNX1
PhosphoSite PhosphoSite-Q9NNX1
TrEMBL
UniProt Splice Variant
Entrez Gene 7286
UniGene Hs.489922
RefSeq NP_064512
HUGO HGNC:12422
OMIM 600087
CCDS CCDS1000
HPRD 02516
IMGT
EMBL AF254260 AF254850 AF254851 AF254852 AF254854 AF254855 AF254856 AF254857 AF254858 AF254859 AF254860 AK026989 AK075001 AK315414 AL136917 AL365436 BC002933 BC008301 CH471121
GenPept AAF78913 AAF78914 AAH02933 AAH08301 BAB15615 BAC11346 BAG37804 CAB66851 CAI16591 CAI16592 EAW53429 EAW53430 EAW53431 EAW53433

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca