InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: OAZ3

Summary

InnateDB Gene

IDBG-102418.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OAZ3

Gene Name

ornithine decarboxylase antizyme 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000143450

Encoded Proteins

IDBP-102422

ornithine decarboxylase antizyme 3

IDBP-226870

ornithine decarboxylase antizyme 3

IDBP-388603

ornithine decarboxylase antizyme 3

IDBP-721753

IDBP-722614

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. In contrast to antizymes 1 and 2, which are widely expressed throughout the body, the expression of this gene product (antizyme 3) is restricted to testis germ cells, and thus it is a possible candidate for heritable forms of human male infertility. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:151762969-151771332

Strand

Forward strand

Band

q21.3

Transcripts

ENST00000321531	ENSP00000313922
ENST00000400999	ENSP00000383784
ENST00000453029	ENSP00000415904
ENST00000479764	ENSP00000463055
ENST00000577465
ENST00000582415	ENSP00000463692

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0008073	ornithine decarboxylase inhibitor activity
GO:0015489	putrescine transmembrane transporter activity
GO:0071532	ankyrin repeat binding

Biological Process

GO:0006521	regulation of cellular amino acid metabolic process
GO:0007283	spermatogenesis
GO:0015847	putrescine transport
GO:0034641	cellular nitrogen compound metabolic process
GO:0043086	negative regulation of catalytic activity
GO:0043666	regulation of phosphoprotein phosphatase activity
GO:0044281	small molecule metabolic process
GO:0045732	positive regulation of protein catabolic process
GO:1902268	negative regulation of polyamine transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0036126	sperm flagellum
GO:0072562	blood microparticle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028141

View Gene Order

ENSBTAG00000021591

Not yet available

Pathways

NETPATH

REACTOME

REACT_13565

Regulation of ornithine decarboxylase (ODC) pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.587578 Hs.713789

RefSeq

NM_001134939 NM_001301371 NM_016178

HUGO

OMIM

CCDS

CCDS58028

HPRD

18670

IMGT

EMBL

GenPept

RNA Seq Atlas