Homo sapiens Gene: OAZ3
Summary
InnateDB Gene IDBG-102418.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OAZ3
Gene Name ornithine decarboxylase antizyme 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143450
Encoded Proteins
ornithine decarboxylase antizyme 3
ornithine decarboxylase antizyme 3
ornithine decarboxylase antizyme 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. In contrast to antizymes 1 and 2, which are widely expressed throughout the body, the expression of this gene product (antizyme 3) is restricted to testis germ cells, and thus it is a possible candidate for heritable forms of human male infertility. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:151762969-151771332
Strand Forward strand
Band q21.3
Transcripts
ENST00000321531 ENSP00000313922
ENST00000400999 ENSP00000383784
ENST00000453029 ENSP00000415904
ENST00000479764 ENSP00000463055
ENST00000577465
ENST00000582415 ENSP00000463692
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0008073 ornithine decarboxylase inhibitor activity
GO:0015489 putrescine transmembrane transporter activity
GO:0071532 ankyrin repeat binding
Biological Process
GO:0006521 regulation of cellular amino acid metabolic process
GO:0007283 spermatogenesis
GO:0015847 putrescine transport
GO:0034641 cellular nitrogen compound metabolic process
GO:0043086 negative regulation of catalytic activity
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0044281 small molecule metabolic process
GO:0045732 positive regulation of protein catabolic process
GO:1902268 negative regulation of polyamine transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0036126 sperm flagellum
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of amino acids and derivatives pathway
Regulation of ornithine decarboxylase (ODC) pathway
Metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q5SZR7
UniProt Splice Variant
Entrez Gene 51686
UniGene Hs.587578 Hs.713789
RefSeq NM_001134939 NM_001301371 NM_016178
HUGO HGNC:8097
OMIM 605138
CCDS CCDS58028
HPRD 18670
IMGT
EMBL AL589765
GenPept
RNA Seq Atlas 51686