InnateDB Protein
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IDBP-102422.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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OAZ3
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Protein Name
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ornithine decarboxylase antizyme 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000313922
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InnateDB Gene
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IDBG-102418 (OAZ3)
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Protein Structure
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Function |
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells. {ECO:0000269PubMed:17900240}.
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Subcellular Localization |
Nucleus. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Testis specific.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0006521
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regulation of cellular amino acid metabolic process
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GO:0007283
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spermatogenesis
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GO:0015847
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putrescine transport
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GO:0034641
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cellular nitrogen compound metabolic process
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GO:0043086
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negative regulation of catalytic activity
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GO:0043666
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regulation of phosphoprotein phosphatase activity
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GO:0044281
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small molecule metabolic process
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GO:0045732
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positive regulation of protein catabolic process
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GO:1902268
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negative regulation of polyamine transmembrane transport
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Cellular Component |
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PDB ID |
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InterPro |
IPR002993
Ornithine decarboxylase antizyme
IPR016181
Acyl-CoA N-acyltransferase
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PFAM |
PF02100
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UMX2
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PhosphoSite |
PhosphoSite-Q9UMX2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51686
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UniGene |
Hs.713789
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RefSeq |
NP_057262
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HUGO |
HGNC:8097
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OMIM |
605138
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CCDS |
CCDS58028
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HPRD |
18670
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IMGT |
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EMBL |
AF175296
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GenPept |
AAD51734
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