Version 5.4
Homo sapiens Gene: PGLYRP3
Summary
InnateDB Gene IDBG-102636.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGLYRP3
Gene Name peptidoglycan recognition protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159527
Encoded Proteins
IDBP-102638
peptidoglycan recognition protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20418257
PGLYRP3 is a secreted innate immunity protein that is expressed on body surfaces, mucous membranes, and in secretions (saliva, sweat) and is conserved from insects to mammals, it recognizes bacterial peptidoglycan, and functions in antibacterial immunity and inflammation.
PMID 21439073
PGLYRP3 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.
PMID 21602801
PGLYRP3 binds to Gram-positive bacterial wall and activates a protein-sensing two-component system to induce bacterial death. PLGYRP3-mediated activation results in membrane depolarization and cessation of peptidoglycan, protein, and RNA/DNA synthesis, as well as the production of hydroxyl radicals.
PMID 22099350
PGLYRP3, when stimulated with peptidoglycan, has an anti-inflammatory effect on intestinal epithelial cells. PGLYRP3 knocking down enhanced the expression of PGN-induced inflammatory cytokines.
InnateDB Annotation from Orthologs
Summary
PMID 21439073
[Mus musculus] Pglyrp3 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.
PMID 21602801
[Mus musculus] Pglyrp3 binds to Gram-positive bacterial wall and activates a protein-sensing two-component system to induce bacterial death. PLGYRP1-mediated activation results in membrane depolarization and cessation of peptidoglycan, protein, and RNA/DNA synthesis, as well as the production of hydroxyl radicals. (Demonstrated in human)
PMID 22099350
[Mus musculus] Pglyrp3, when stimulated with peptidoglycan, has an anti-inflammatory effect on intestinal epithelial cells. PGLYRP3 knocking down enhanced the expression of PGN-induced inflammatory cytokines. (Demonstrated in human)
Entrez Gene
Summary This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153297862-153310718
Strand Reverse strand
Band q21.3
Transcripts
ENST00000290722 ENSP00000290722
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0016019 peptidoglycan receptor activity
GO:0042834 peptidoglycan binding
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016045 detection of bacterium
GO:0032689 negative regulation of interferon-gamma production
GO:0032827 negative regulation of natural killer cell differentiation involved in immune response
GO:0044117 growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042244
View Gene Order
ENSBTAG00000021443
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.348266
RefSeq NM_052891
HUGO
OMIM
CCDS CCDS1035
HPRD 16297
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca